Zopiclone: Uses, Interactions, Mechanism of Action


What is Zopiclone?

Zopiclone is a type of medicine or drug which is prescribed to those who suffer from sleep issues like insomnia or sleep awakening. Use of this medicine helps one to sleep quickly and have a sound sleep throughout the night. It is a type of sleeping pill which helps to avoid sleep awakenings. It belongs to the category of sedative hypnotics. Zopiclone is an oral medicine which is available under different brands like Imovane, Dopareel etc. It is classified as a non-benzodiazepine hypnotic or sedative which when overdose can be life threatening as well. 

Side effects of Zopiclone:

Long term use of any sleeping pill can lead to adverse outcomes which can be moderate to severe. Same is the case of Zopiclone. If this sleeping drug is used for an extended period of time it can lead to serious side effects. These side effects are as follows:

  1. Heart palpitations.
  2. Sore throat.
  3. Lethargy.
  4. Pain in abdomen.
  5. Nightmares.
  6. Chest pain.
  7. Dry mouth.
  8. Sinusitis.
  9. Depression.
  10. Dizziness.
  11. Amnesia which is loss of memory either partially or totally.
  12. Sore throat.
  13. Zopiclone use can impair motor skills.
  14. Sleepwalking.
  15. Confusion.
  16. Unsteadiness.
  17. Coordination issues.
  18. Mood changes.
  19. Aggressiveness which can be less common.

Zopiclone Uses:

Some of the uses of Zopiclone:

  1. Zopiclone is used to treat short term insomnia.
  2. It is also effective for treating sleep awakening or waking up in the middle of the night.
  3. It can also be used to treat sleep disorder which is caused as a result of any mental illness or accident.
  4. It results in lower chances of rebound insomnia.

Zopiclone Interactions:

It is extremely important to let your doctor know about any other medications that you are taking when you are about to start Zopiclone as Zopiclone can interact with many drugs and cause serious side effects. Some of the medicine which can interact with Zopiclone and should be avoided include:

  1. Morphine.
  2. Oxymorphone.
  3. Meclizine.
  4. Fentanyl.
  5. Hydrocodone.
  6. Buprenorphine.

Where To Buy Zopiclone?

Zopiclone is a prescription only drug which means that it cannot be purchased without a prescription from any drug store. Prescription from the doctor is mandatory to buy Zopiclone tablets.  Due to these restrictions, people can also buy online Zopiclone from drug sellers which operate over the web and do not demand prescription. 

Dose of Zopiclone:

The dose of Zopiclone is decided by the doctor and varies from patient to patient. Certain factors need to be kept in mind while deciding the dose of Zopiclone like number of doses taken in a day, total duration of taking Zopiclone and the time or gap between one dose to taking the next dose. However, the average dose for treating insomnia is 5 mg to 7.5 mg at bedtime. If the dose of Zopiclone is missed it is strongly advised to never double the dose instead take the next dose. Overdosing Zopiclone can lead to issues like loss of consciousness, severe drowsiness, reduction in physical activity, unusual sleepiness etc. 


Use of Zopiclone is not recommended in those people who have a history of alcohol abuse or currently do so. Moreover, there are many medical issues in which it is recommended to avoid using Zopiclone. These conditions are as follows:

  1. Kidney disease.
  2. Mental depression.
  3. Drug abuse or dependency.
  4. Chronic lung diseases.
  5. Asthma.
  6. Emphysema.
  7. Sleep apnea.
  8. Liver diseases.
  9. Myasthenia gravis.
  10. Bronchitis.

Precautions To Take While Using Zopiclone:

It is recommended to follow certain precautions while taking Zolpidem. First thing to note is that if you are having sleeping related issues which go beyond a period of 10 days or more it can be due to any other underlying illness for which it is advised to consult the doctor rather than taking Zolpidem for overcoming such sleep issues. Moreover, there are certain drowsiness-causing medicines that can interact with Zolpidem or if taken with Zolpidem can lead to serious outcomes. Moreover, taking alcohol with sleeping pills like Zolpidem may also result in adverse outcomes. Moreover, if you have any dental appointment or surgery which requires you to put you in a drowsy state, do let the doctor know that you are using Zolpidem. It is advised to take Zolpidem only right before going to bed as if taken otherwise may interact with daily activities. One must know how to react while being on Zopiclone especially while driving or operating or handling machinery. Moreover, if you see any change in your behavior while taking Zolpidem you should let the doctor know immediately. 

What Happens When You Stop Taking Zopiclone?

Many users may face side effects after they have stopped taking this medication which should be immediately conveyed to the primary care physician. These side effects may include increased sweating, increased difficulty in sleeping, pain in stomach and cramps, nausea, muscle cramps, seizures, irritability, anxiety etc. 

Mechanism Of Action:

Zopiclone which is a type of non-benzodiazepine hypnotic which increases the neurotransmitter activity in the brain. This involves transmitting the chemicals from the brain. This in turn gives a calming effect to the body and prepares a person to sleep. The neurotransmitter activity helps the muscles to relax and helps to reduce anxiety. 

Who Should Avoid Taking Zopiclone:

Zopiclone should not be taken by children who are below 18 years of age. Also those people who suffer from breathing problems and those who suffer from sleep apnea are advised to not take this sleep sedative. Moreover it is suggested that the elderly patients take modest doses of Zolpidem to avoid any serious side effects. Also those who are suffering from any mental disorder or have a history of psychiatric illness in the past should try to avoid using Zopiclone. Also pregnant ladies and those who are currently breastfeeding should avoid taking this medicine as in pregnant women its use can lead to withdrawal symptoms in newborn. And it can pass through breast milk in small amounts which can be dangerous for the baby.

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