Over the Counter Sleeping Pills


Insomnia is a common sleep disorder characterised by difficulties falling asleep or staying asleep for long periods of time (waking up at night or early in the morning). Antihistamine sedatives (drugs used to treat allergies) can be used as a temporary solution to sleep issues.

I’ll go over all of the over-the-counter (OTC) sleeping pills medicines available in the UK in this piece. Sedative antihistamines are found in all non-prescription sleeping medications available in the United Kingdom. The following topics will be covered:

What Causes insomnia?

A variety of factors can contribute to insomnia. Stress and anxiety are two typical culprits. Before considering sleeping drugs, you should always consider changing your sleeping patterns. There are a plethora of internet tools, including the NHS and Mind websites that can help you improve your sleep. 

OTC Sleeping Pills UK: Active Ingredients

Sedative antihistamines are the primary active ingredient in all over-the-counter ‘sleeping’ medications. Diphenhydramine and promethazine are two sedative antihistamines used in the manufacture of OTC sleeping pills in the United Kingdom.

Both diphenhydramine and promethazine are antihistamines from the first generation. Drowsiness and sedation are the most common side effects linked with the usage of first-generation antihistamines, which is related to their propensity to pass the blood-brain barrier (BBB). The BBB usually prevents dangerous poisons, viruses, and medications from entering the brain.

When opposed to the first generation of antihistamines, the second generation of antihistamines, such as loratadine and cetirizine, which can also be acquired over the counter for the treatment of allergies, cross the blood-brain barrier in substantially lesser levels.

As a result, dizziness is a rare adverse effect of certain antihistamines. Antihistamines of the second generation are generally characterized as non-drowsy antihistamines.

Sedative Antihistamines: Common Side Effects

Side effects are possible for people who take sedative antihistamines. If you experience any of the following side effects, do not use or Buy sleeping pills (OTC). The headings below covers some of the most common side effects that might occur after taking sedative antihistamine-containing OTC sleeping pills. There is no information on how common, very common, or unusual promethazine is.


  • Fatigue,
  • Sedation,
  • drowsiness,
  • dizziness
  • Sedation,
  • drowsiness,
  • dizziness


  • Drowsiness,
  • confusion,
  • dizziness,
  • headaches,
  • Dry mouth and throat,
  • stomach upsets

Tolerance and Addiction

Are OTC Sleeping Pills Addictive?

Over-the-counter sedative antihistamines like diphenhydramine and promethazine do not appear to be addictive, according to research. Purchasing diphenhydramine with promethazine is relatively risk-free.

OTC sleeping pills medications containing diphenhydramine and promethazine can help with sleeping problems in the short term.

However, it has been shown that when used on a regular basis, tolerance develops quickly (Vande Griend, Anderson, 2003), usually within a few days after beginning treatment.

Simply put, when antihistamines are taken on a daily basis, you are less likely to benefit from the treatment, such as help falling asleep.

OTC Sleeping Pills UK: Differences Between Drugs

The biggest difference between the two medications in terms of patient preference is the length of effect. Each antihistamine does not have a clearly defined period of action; however, it is estimated that:

Diphenhydramine-containing sleeping pills last 4 to 8 hours.

Promethazine-containing sleep aids last between 8 and 12 hours.

The values shown above are only estimates. Patients are frequently warned that after taking any of the sedative antihistamines, they may feel tired or drowsy in the morning.

Who Should Not Have Otc Sleeping Tablets? 

Patients who are not in the licensed age group (see details for each specific product) and they are taking or have just ceased     taking monoamine oxidase inhibitors (MOI) (in the last 14 days)

There are also other ‘cautions’ on the use that are related to various illnesses, such as

  • asthma
  • narrow-angle glaucoma
  • epilepsy or medicine
  • such as tricyclic antidepressants
  • such as amitriptyline

Please read this article before taking and Buy sleeping pills (over-the-counter). Before using, please read the product information booklet or consult with a pharmacist for further information. After buy sleeping pills, keep them away from childrens.

 Where To Buy Sleeping Pills UK?

All diphenhydramine and promethazine-containing medications are classed as pharmacy-only medicines (P). Only registered pharmacies, including online chemists, can sell P products. Customers cannot “buy sleeping pills UK” in the UK that are not over-the-counter without a doctor prescription. Customers must obtain P medications from the pharmacy counter because they are not available for self-selection.

What Is the Best Over-The-Counter Sleeping Aid in the United Kingdom?

There is no proof that promethazine is better than diphenhydramine or vice versa. Both medications enter the bloodstream quickly, causing sedation and drowsiness. Promethazine has a longer half-life in the body, which may result in a longer period of drowsiness.

In light of this, Phenergan Night-Time and Phenergan 25mg (each tablet contains 25mg of promethazine) may be the best over-the-counter sleeping pills in the UK.

Options for Over-the-Counter Sleeping Pills in the United Kingdom:

1. The best sleeping pills in the UK contain diphenhydramine.

1.1 Nytol Original and Nytol One a Night

1.            Nytol Original: each tablet contains 25mg of diphenhydramine hydrochloride.

2.            Nytol One a Night: each tablet contains 50mg of diphenhydramine hydrochloride.

1.2 Nytol Original alternative products

All of the products listed below have the same age restrictions and usage limitations.

  • Numark Sleep Aid 25mg Tablets
  • Superdrug Sleep Aid 25mg Tablets
  • Sleepeaze 25mg Tablets
  • Asda NightTime Sleep Aid Tablets 25milligrammes
  • Morrison’s Sleep Aid 25mg Tablets
  • Tesco Sleep Aid 25mg Tablets

1.3. Over the counter sleeping aids: Nytol liquid

1.4. Panadol Night (Panadol Night Pain)

1.5. Cold and flu products containing diphenhydramine

2. Promethazine-Containing, the Best over the Counter Sleeping Pills UK

In the United Kingdom, two brands of promethazine sleeping aid products are available:

2.1. Sominex

2.2. Phenergan Night-Time

  2.2.1. Phenergan (10mg and 25mg)

3. Over The Counter Sleeping Pills: Herbal Products

Customers can also Buy sleeping pills (otc) containing herbal ingredients and also have a good choice of herbal products, which can be used as an aid to help with sleeping problems. Herbal remedies are based on traditional use. The most common herb used is valerian. The effectiveness and availability of herbal products in the management of insomnia will be subject to a separate review.

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